Cov kab mob latently muaj cov kab mob HIV-1 proviral DNA genome feem ntau koom ua ke rau hauv heterochromatin, tso cai rau kev pheej hmoo ntawm transcriptionally ntsiag to proviruses.Hypoacetylation ntawm histone proteins los ntawm histone deacetylases (HDAC) yog koom nrog hauv kev saib xyuas ntawm HIV-1 latency los ntawm kev tawm tsam tus kab mob kis.Tsis tas li ntawd, cov kab mob hauv lub cev, tshwm sim los ntawm cov kab mob polymicrobial subgingival xws li Porphyromonas gingivalis, yog cov kab mob uas muaj ntau tshaj plaws ntawm noob neej.Ntawm no peb qhia txog cov teebmeem ntawm P. gingivalis ntawm HIV-1 replication.Qhov kev ua no tuaj yeem suav tau rau cov kab mob kab lis kev cai supernatant tab sis tsis yog rau lwm yam kab mob xws li fimbriae lossis LPS.Peb pom tias qhov kev ua haujlwm HIV-1-inducing no tau zoo nyob rau hauv qis molecular pawg (<3 kDa) feem ntawm kab lis kev cai supernatant.Peb kuj tau pom tias P. gingivalis ua rau muaj siab ntawm butyric acid, ua lub zog inhibitor ntawm HDACs thiab ua rau histone acetylation.Chromatin immunoprecipitation assays qhia tias cov corepressor complex muaj HDAC1 thiab AP-4 tau dissociated los ntawm HIV-1 ntev davhlau ya nyob twg rov txhawb nqa raws li stimulation nrog kab lis kev cai supernatant concomitantly nrog lub koom haum ntawm acetylated histone thiab RNA polymerase II.Yog li peb pom tias P. gingivalis tuaj yeem ua rau HIV-1 reactivation los ntawm kev hloov kho chromatin thiab tias butyric acid, ib qho ntawm cov kab mob metabolites, yog lub luag haujlwm rau cov nyhuv no.Cov txiaj ntsig no qhia tau tias cov kab mob hauv lub cev tuaj yeem ua rau muaj kev pheej hmoo rau HIV-1 rov ua haujlwm rau cov tib neeg muaj mob thiab tuaj yeem ua rau muaj kev sib kis ntawm tus kabmob.
Post lub sij hawm: Sep-10-2020